Biomedical and Biological Flows
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Silicone Sylgard 184 (PDMS) is commonly used when manufacturing geometries for bioflow studies due to its optical transparency and compliant nature. However, for use with particle image velocimetry (PIV), a suitable blood analog working fluid is needed which both matches the physical properties of blood...

4D flow magnetic resonance imaging (MRI) allows for in vivo acquisition of time-resolved three-dimensional (3D) blood flow, thus enabling quantitative analysis of volumetric, time-varying hemodynamic quantities such as flow rates, wall shear stress (WSS), pressure difference, etc. 4D flow MRI is based on the phase...

Echocardiogram Particle Image Velocimetry (echoPIV) is an emerging method for cardiac flow visualization. EchoPIV tracks acoustic-opaque bubbles introduced into the blood stream using block-matching methods. Despite increased interest, echoPIV is not routinely performed, as contrast enhancement is not clinically indicated unless initial image quality is...

Visualization and quantitation of multi-directional cardiovascular flow without the need for sedation or contrast is desirable across all practices of cardiology. Intraventricular flow mapping (iVFM) is one such method for multi-direction visualization. iVFM estimates the transverse flow from color Doppler ultrasound using the continuity equation....

Pressure measured from the cardiovascular system is widely used to diagnose disease. Pressure reconstruction methods are increasingly of interest with the development of 4D flow magnetic resonance imaging (MRI) which noninvasively measures time-resolved velocity fields in-vivo. However, several error sources and limitations inherent to in...

For cancer to metastasize, tumor cells must invade the local tissue and grow and proliferate once they arrive. Tumor cell heterogeneity, the presence of multiple types of cancer cells within a tumor, can increase cell proliferation and invasion through interactions, increasing the potential for metastasis....

Despite its clinical importance, accurately assessing the progression and risk of rupture of cerebral aneurysms is challenging. Hemodynamic factors play an important role in aneurysm progression, but previous studies have reported contradictory findings, preventing specific mechanisms from being defined. To date, the vast majority of studies...