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Improving Our Understanding of the Mechanisms Behind Protein Aggregation in Biologics The stability of protein treatments, such as enzyme replacements and monoclonal antibodies, is an ongoing challenge in modern medicine. Using the model protein BSA, we methodically analyze the role of different mechanical and interfacial stresses in...

Histological analysis is vital for understanding tissue structure and diagnosing diseases, but manual segmentation of tissue layers is often time-consuming and inconsistent. This unsupervised method segments skin tissue layers—dermis, subcutaneous, and muscle using K-means clustering, neighborhood histograms, and Dijkstra's algorithm. Unlike prior approaches, it requires...

The objective of this study is to introduce a novel approach for detecting atrial fibrillation (AFib) by analyzing Lead II electrocardiograms (ECGs) using a distinct set of features. To achieve this goal, we employed advanced signal processing techniques, including proper orthogonal decomposition, continuous wavelet transforms,...

Transition to turbulence in pulsatile pipe flow is of interest in a variety of biological flow domains including in the left ventricle and aorta, aneurysms, and stenotic vessels. Transitional flow can critically alter distributions of important hemodynamic parameters such as wall shear stress (WSS). Many previous...