Measurement and Data Science
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With advancements in biotechnology, the production of highly concentrated antibody formulations for subcutaneous injections is becoming common in the biopharmaceutical industry. Measurement of transport and more importantly diffusion of proteins in tissues is essential in drug development. There is evidence suggesting that the assumption of the...

4D flow magnetic resonance imaging (MRI) allows for the in vivo acquisition of time-resolved three-dimensional (3D) blood flow, enabling the evaluation of hemodynamic quantities for cerebral aneurysms (CAs). However, the accuracy of flow-derived hemodynamic quantities such as pressure and wall shear stress (WSS) is affected...

4D flow magnetic resonance imaging (MRI) allows for in vivo acquisition of time-resolved three-dimensional (3D) blood flow, thus enabling quantitative analysis of volumetric, time-varying hemodynamic quantities such as flow rates, wall shear stress (WSS), pressure difference, etc. 4D flow MRI is based on the phase...

Echocardiogram Particle Image Velocimetry (echoPIV) is an emerging method for cardiac flow visualization. EchoPIV tracks acoustic-opaque bubbles introduced into the blood stream using block-matching methods. Despite increased interest, echoPIV is not routinely performed, as contrast enhancement is not clinically indicated unless initial image quality is...

The uncertainty in a planar PIV measurement has been a topic of great interest in the last decade. Here, we present a new direct uncertainty estimation method for Particle Image Velocimetry (PIV), that uses the correlation plane as a model for the probability density function...

Volumetric Particle Tracking Velocimetry (PTV) non-invasively measures the 3D velocity field by recording successive snapshots of the tracer particle motion using a multi-camera set-up. A key step in the measurement chain is reconstructing the 3D particle location using the multi-camera projected particle images. However, the...

Pressure measured from the cardiovascular system is widely used to diagnose disease. Pressure reconstruction methods are increasingly of interest with the development of 4D flow magnetic resonance imaging (MRI) which noninvasively measures time-resolved velocity fields in-vivo. However, several error sources and limitations inherent to in...

Estimating the probability density function (PDF) of the random motion of particles has many applications. For example, measuring diffusion, rheology, temperature, Reynolds stresses in turbulent flows, and uncertainty in velocity measurements. Current methods based on cross-correlation (CC) of image ensembles estimate an assumed Gaussian PDF's...