The transition from fetal to neonatal circulation significantly impacts systemic right ventricle (SRV) function, but traditional imaging methods struggle to capture these changes. This study used advanced echocardiographic analysis to compare biomechanical and flow alterations in 10 SRV patients and 12 healthy controls, measured at 33 weeks gestation and after birth. We...
Four-dimensional flow MRI (4D flow MRI) is a powerful tool for assessing right ventricular (RV) flow dynamics in congenital heart disease, but its limited availability restricts widespread use. Doppler Velocity Reconstruction (DoVeR)from conventional echocardiography offers a promising alternative, but its accuracy compared to 4D flow MRI needs further validation....
Repaired tetralogy of Fallot (RTOF) patients often develop right ventricular (RV) dysfunction due to chronic pulmonary regurgitation, but detecting early changes in intracardiac flow remains challenging. While advanced imaging techniques like four-dimensional cardiac magnetic resonance (CMR) provide insights into vorticity and flow energy loss (FEL),...
This study introduces a novel wall shear stress (WSS) estimation method for 4D flow MRI. The method improves the WSS accuracy by using the reconstructed pressure gradient and the flow-physics constraints to correct velocity gradient estimation. The method was tested on synthetic 4D flow data...
Interface motion and hydrodynamic shear of the liquid slosh during the insertion of syringes upon autoinjector (AI) activation may damage the protein drug molecules. We experimentally investigate the interfacial motion and hydrodynamic shear due to the acceleration and deceleration of syringes. No study to date...
We present a fully automated, adaptive, and robust feature-based cell tracking algorithm for the accurate detection and tracking of cells using time-lapse images. Our algorithm tackles measurement limitations twofold. First, we use Hessian filtering and adaptive thresholding to detect the cells in images, overcoming spatial...
With advancements in biotechnology, the production of highly concentrated antibody formulations for subcutaneous injections is becoming common in the biopharmaceutical industry. Measurement of transport and more importantly diffusion of proteins in tissues is essential in drug development. There is evidence suggesting that the assumption of the...
4D flow magnetic resonance imaging (MRI) allows for the in vivo acquisition of time-resolved three-dimensional (3D) blood flow, enabling the evaluation of hemodynamic quantities for cerebral aneurysms (CAs). However, the accuracy of flow-derived hemodynamic quantities such as pressure and wall shear stress (WSS) is affected...
Silicone Sylgard 184 (PDMS) is commonly used when manufacturing geometries for bioflow studies due to its optical transparency and compliant nature. However, for use with particle image velocimetry (PIV), a suitable blood analog working fluid is needed which both matches the physical properties of blood...
4D flow magnetic resonance imaging (MRI) allows for in vivo acquisition of time-resolved three-dimensional (3D) blood flow, thus enabling quantitative analysis of volumetric, time-varying hemodynamic quantities such as flow rates, wall shear stress (WSS), pressure difference, etc. 4D flow MRI is based on the phase...