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Recent Posts

Catch up on the latest work and news from the Vlachos Research Group.

This work introduces a method to estimate the uncertainty of the pressure fields reconstructed from particle image velocimetry / particle tracking velocimetry (PIV/PTV) measurements by propagating the instantaneous velocity vector uncertainty through the pressure reconstruction. The uncertainty propagations through the calculation and integration of pressure...

Interface motion and hydrodynamic shear of the liquid slosh during the insertion of syringes upon autoinjector (AI) activation may damage the protein drug molecules. We experimentally investigate the interfacial motion and hydrodynamic shear due to the acceleration and deceleration of syringes. No study to date...

Pharmaceutical industry focuses on developing prefilled syringe and autoinjector (AI) products by expanding features and capabilities. However, most of them might not be aware of an undesired phenomenon that may occur during drug solution injection called cavitation collapse. Cavitation is a phenomenon in which rapid...

We present a fully automated, adaptive, and robust feature-based cell tracking algorithm for the accurate detection and tracking of cells using time-lapse images. Our algorithm tackles measurement limitations twofold. First, we use Hessian filtering and adaptive thresholding to detect the cells in images, overcoming spatial...

With advancements in biotechnology, the production of highly concentrated antibody formulations for subcutaneous injections is becoming common in the biopharmaceutical industry. Measurement of transport and more importantly diffusion of proteins in tissues is essential in drug development. There is evidence suggesting that the assumption of the...

Particle Image Velocimetry (PIV) is a widely used non-invasive approach to finding a fluid flow velocity using tracer particles. Performing PIV measurement where the Signal-to-Noise Ratio (SNR) in the correlation plane is low can be unreliable and challenging. To address this issue, ensemble PIV has...